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1.
Eur J Ophthalmol ; 31(4): 1779-1784, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32811165

RESUMO

OBJECTIVE: The examination of pupillary light reflexes is widely employed to evaluate the autonomic system's balance, ocular, and neurological conditions, typically evaluated by qualitative observation. To describe and evaluate the inter-rater reliability and agreement of pupillometric values obtained with a novel semi-automatic mobile pupillography app. METHODS: Two examiners and two graders perform the measurements with an android app which corrects the device-face distance, measure the maximum contraction of the pupil, and calculates its slope, in a hospital room setting with three levels of environmental light intensity: <100, 101 to 200, and 201 to 300 lux, at 200, 400, 600, 900, 1200, and 1500 milliseconds. RESULTS: Sixty healthy individuals, aged 18 to 45, were included; 85% had brown eyes. The reliability of the pupil/iris ratio had Ri = 70% to 88%, and bland Altman graphics show a uniform agreement. The pupillography curves show a similar slope at different light intensities, during the contraction phase. CONCLUSION: There were very good repeatability and inter-rater reproducibility of the measurements at average levels of illumination in examination rooms, even in dark-eyed people. This app provides a highly promising approach to pupillary measurements in clinical practice.


Assuntos
Aplicativos Móveis , Técnicas de Diagnóstico Oftalmológico , Cor de Olho , Humanos , Pupila , Reprodutibilidade dos Testes
2.
J Clin Pediatr Dent ; 41(1): 48-52, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28052214

RESUMO

OBJECTIVE: The objective of this study was to evaluate the effects of pit and fissure sealant mixed with silver nanoparticles on dental caries, by means of monthly measurement of fluorescence with DIAGNOdent over six months. STUDY DESIGN: This study was divided in two phases: experimental and clinical. In the experimental phase, the adhesion and microleakage of the pit and fissure sealant experiment were evaluated. Two groups of 10 teeth, without serious carious lesions, were included. Conventional (group A) and silver nanoparticles (group B) were added to the pit and fissure sealant. For the clinical phase, a split-mouth study was performed on 40 children aged 6-10 years old with healthy, erupted permanent first molars. A conventional pit and fissure sealant or a silver nanoparticle-mixed sealant was randomly placed. Repeated measures analysis was performed. RESULTS: Conventional sealant presented an average microleakage of 30.6%, and the silver nanoparticle-mixed sealant showed 33.6% (P=NS). A three times greater reduction in fluorescence was found in the silver nanoparticles group compared to the conventional group (P<0.05). No sex- or age-based associations were found. CONCLUSIONS: The silver nanoparticle-mixed sealant reduced tooth demineralization significantly and likely increased remineralization, compared to the conventional sealant.


Assuntos
Cárie Dentária/prevenção & controle , Nanopartículas Metálicas , Selantes de Fossas e Fissuras/uso terapêutico , Prata/uso terapêutico , Criança , Método Duplo-Cego , Humanos , Selantes de Fossas e Fissuras/química , Prata/análise
4.
Cir Cir ; 85(3): 220-224, 2017.
Artigo em Espanhol | MEDLINE | ID: mdl-27131979

RESUMO

BACKGROUND: The high frequency of post-operative pain in the patients after laparoscopic cholecystectomy has led to the need to use multiple analgesic therapies. These include auriculotherapy, although not very good results have been obtained with the traditional techniques. OBJECTIVE: To evaluate the effectiveness of modified auriculotherapy for post-operative pain control in laparoscopic cholecystectomy patients. MATERIAL AND METHODS: Double-blind controlled clinical trial. Experimental group: Different points ear puncture with xylocaine without needles vs. placebo group. Post-operative visual analogue scale (VAS) at 6, 12, 18, 24, 36, and 48h and rescue doses of analgesics, were measured in both groups. RESULTS: At 6h post-operative, 87% of the auriculotherapy group had a VAS of<4 vs. 48% of placebo group (p = 0.004), and 96 vs. 74% (p = 0.008) at 18hours. At 24, 36 and 48h after surgery there were no differences, and as all of the patients in both groups had a VAS<4, they were discharged to the hospital. CONCLUSIONS: Modified auriculotherapy was better to the conventional analgesics for post-operative pain control in patients subjected to laparoscopic cholecystectomy.


Assuntos
Auriculoterapia , Colecistectomia Laparoscópica/efeitos adversos , Dor Pós-Operatória/terapia , Administração Tópica , Adulto , Analgésicos/uso terapêutico , Anestésicos Locais/administração & dosagem , Método Duplo-Cego , Procedimentos Cirúrgicos Eletivos , Feminino , Humanos , Lidocaína/administração & dosagem , Masculino , Pessoa de Meia-Idade , Adulto Jovem
5.
Arch. latinoam. nutr ; 63(3): 224-231, sep. 2013. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-749964

RESUMO

La evidencia sobre los posibles mecanismos de utilización de los ácidos grasos Omega 3 para mediar la obesidad requiere continuar con estudios clínicos con metodologías concretas. El objetivo fue evaluar mediante impedancia bioeléctrica el efecto de la suplementación de omega 3 sobre el Indicé de Masa Corporal (IMC), Índice Cintura Cadera (ICC) y composición corporal en mujeres obesas. Participaron 60 mujeres obesas adultas (IMC >30 Kg/m²) que fueron aleatorizadas en 3 grupos: Grupo 1) placebo, vitamina E (200 UI), Grupo 2) 1 g de omega 3) y Grupo 3) 2 g de omega 3. Todas recibieron dieta hipocalórica y ejercicio moderado. Se midieron; peso, IMC, índice cintura cadera y distribución grasa al inicio y cada mes por tres meses. Los resultados muestran que la suplementación con omega 3 tuvo una relación dosis respuesta disminuyendo significativamente el peso, IMC y la masa grasa total, en comparación con el grupo control. Estos efectos dependieron del tiempo y cantidad de Omega 3 suplementada, cuando se ajustó por el grado de cumplimiento de ejercicio, apego a la dieta y edad. Concluimos que la suplementación con Omega 3 es un coadyuvante eficaz en el manejo de la obesidad en mujeres premenopáusicas.


Evidence on the possible mechanisms for the use of Omega 3 fatty acids to mediate obesity requires clinical studies continue with specific methodologies. The aim was to assess the effect of omega-3 supplementation on Body Mass Index (BMI), Wais - Hip Index (WHI) and body composition of obese women using bioelectrical impedance. Subjects 60 premenopausal obese women (BMI > 30Kg/m²) were randomly assigned to 3 groups: Group 1) placebo, vitamin E (200 IU), group 2) 1 g of omega and group 3) 2 g of omega-3. All of them received a low calorie diet and moderate exercise. Weight, BMI, WHI, and fat distribution were measured at the beginning and every month for three months. The results show us Omega-3 supplementation significantly reduced weight, BMI, and total fat mass, compared to the control group, a dose-response effect. These effects depended on the time and amount of Omega 3 supplemented, when the degree of compliance of exercise, adherence to the diet and age were controlled. In conclusion the supplementation with omega- 3 is an efficient method in the management of obesity in premenopausal women.


Assuntos
Adulto , Feminino , Humanos , Adulto Jovem , Suplementos Nutricionais , /administração & dosagem , Obesidade/dietoterapia , Composição Corporal , Índice de Massa Corporal , Método Duplo-Cego , Ingestão de Energia , Exercício Físico , Resultado do Tratamento , Circunferência da Cintura
6.
Arch Latinoam Nutr ; 63(3): 224-31, 2013 Sep.
Artigo em Espanhol | MEDLINE | ID: mdl-25362822

RESUMO

Evidence on the possible mechanisms for the use of Omega 3 fatty acids to mediate obesity requires clinical studies continue with specific methodologies. The aim was to assess the effect of omega-3 supplementation on Body Mass Index (BMI), Wais - Hip Index (WHI) and body composition of obese women using bioelectrical impedance. Subjects 60 premenopausal obese women (BMI > 30Kg/m2) were randomly assigned to 3 groups: Group 1) placebo, vitamin E (200 IU), group 2) 1 g of omega and group 3) 2 g of omega-3. All of them received a low calorie diet and moderate exercise. Weight, BMI, WHI, and fat distribution were measured at the beginning and every month for three months. The results show us Omega-3 supplementation significantly reduced weight, BMI, and total fat mass, compared to the control group, a dose-response effect. These effects depended on the time and amount of Omega 3 supplemented, when the degree of compliance of exercise, adherence to the diet and age were controlled. In conclusion the supplementation with omega-3 is an efficient method in the management of obesity in premenopausal women.


Assuntos
Suplementos Nutricionais , Ácidos Graxos Ômega-3/administração & dosagem , Obesidade/dietoterapia , Adulto , Composição Corporal , Índice de Massa Corporal , Método Duplo-Cego , Ingestão de Energia , Exercício Físico , Feminino , Humanos , Resultado do Tratamento , Circunferência da Cintura , Adulto Jovem
7.
Pathog Glob Health ; 106(4): 232-7, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23265424

RESUMO

OBJECTIVES: To identify the variables that predict the failure to treat amoebic liver abscesses. METHODS: We prospectively carried out a case-control study on a cohort of patients who had been diagnosed with amoebic liver abscesses using clinical, ultrasonic, and serologic methods. Patients with pyogenic abscesses, negative ELISA tests for amoebiasis, immunosuppression status, or previous abdominal surgery were excluded. All patients received metronidazole, and those who demonstrated 4 days of unfavorable clinical responses received percutaneous or surgical draining of the abscess. Demographic, laboratory, and ultrasonographic characteristics were assessed as prognostic indications of failure. RESULTS: Of 40 patients with amoebic liver abscess, 24 (mean age: 36·7±11·2 years) responded to medical treatment and 16 (41·8±11·6 years) required drainage, including 14 patients who underwent percutaneous drainage and two patients who required surgery. The albumin level, abscess volume, abscess diameter, and alkaline phosphatase level were all statistically significant (P<0·05) on the bivariate analysis. The highest (>99%) sensitivity and negative predictive value were observed for an abscess volume >500 ml and diameter >10 cm, while the best specificity and positive predictive value were achieved with the combination of low serum albumin level, high alkaline phosphatase level, and large abscess volume or diameter. CONCLUSIONS: The prognostic indications of the failure to treat amoebic liver abscesses include low albumin, high alkaline phosphatase, and large abscess volume or diameter. The combination of these variables is a useful and easy tool for determining appropriate therapy.


Assuntos
Antiprotozoários/administração & dosagem , Abscesso Hepático Amebiano/tratamento farmacológico , Abscesso Hepático Amebiano/cirurgia , Metronidazol/administração & dosagem , Sucção , Adulto , Estudos de Casos e Controles , Estudos de Coortes , Feminino , Humanos , Abscesso Hepático Amebiano/patologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Falha de Tratamento
8.
Pathog Glob Health ; 106(4): 245-8, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23265426

RESUMO

BACKGROUND: Toxic or fulminant colitis due to Entamoeba histolytica infrequently presents but is very serious. Unfortunately, there are numerous contradictory factors related to mortality. METHODS: We analyzed several cases of E. histolytica infection to determine the factors related to mortality. We included patients >15 years of age who were histopathologically diagnosed with amoebic toxic colitis and treated from January 2000 through December 2006. We evaluated demographic, clinical, laboratorial, surgical, and histopathological characteristics. RESULTS: We examined 24 patients and recorded 12 deaths (50%). Twenty patients underwent surgery within a mean time of 24 hours (range: 8-120 hours). Tenesmus and intestinal perforation were determined to be statistically significant (P<0·05) by univariate analysis. Three models of logistic regression were able to determine three statistically significant factors that affected mortality: (1) tenesmus and a lymphocyte count <1·5×10(3) cell/µl; 2) depth of invasion beyond the mucosa and a lymphocyte count <1·5×10(3) cell/µl; 3) time spent with symptoms and perforation. CONCLUSIONS: The mortality rate determined in this study is similar to previously reported series. A low lymphocyte count, significant depth of invasion, and intestinal perforation were determined to be the factors related to increased mortality, while tenesmus and limited amount of time spent with symptoms were associated with survival. Quick diagnosis and appropriate treatment are important factors that reduce mortality.


Assuntos
Disenteria Amebiana/mortalidade , Disenteria Amebiana/patologia , Entamoeba histolytica/patogenicidade , Adolescente , Adulto , Idoso , Disenteria Amebiana/complicações , Disenteria Amebiana/imunologia , Feminino , Humanos , Perfuração Intestinal/diagnóstico , Perfuração Intestinal/mortalidade , Linfopenia/diagnóstico , Linfopenia/mortalidade , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Análise de Sobrevida , Adulto Jovem
9.
J Clin Pediatr Dent ; 36(1): 37-41, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22900442

RESUMO

UNLABELLED: Silver nanoparticles (NNPs) are extensively used for all kinds of antimicrobial applications in medical research. Their efficacy has been demonstrated against Streptococcus mutans, which is associated with dental caries. However their cytotoxic effects on human periodontal tissue are not completely understood. OBJECTIVE: The aim of this study was to evaluate the possible toxic cellular effects of different concentrations and sizes of silver nanoparticles, less than 10 nm, 15-20 nm, and 80-100 nm, respectively, on human periodontal fibroblasts. STUDY DESIGN: Primary culture cells isolated from human periodontal tissue were exposed to 0-1,000 microM silver nanoparticles of each size for 24-, 72-, and 168-hour periods. Cytotoxicity was evaluated with a nonradioactive, soluble MTS/PMS assay. RESULTS: The results demonstrated that silver nanoparticles of less than 20 nm increased cytotoxicity in human periodontal fibroblasts in a dose- and time-dependent manner. CONCLUSION: The 80-100-nm-sized nanoparticles did not modify the viability of human primary culture cells.


Assuntos
Nanopartículas/toxicidade , Ligamento Periodontal/efeitos dos fármacos , Prata/toxicidade , Sobrevivência Celular/efeitos dos fármacos , Fibroblastos/efeitos dos fármacos , Humanos , Tamanho da Partícula , Ligamento Periodontal/citologia , Cultura Primária de Células
10.
J Clin Pediatr Dent ; 35(1): 65-8, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21189767

RESUMO

Silver nanoparticles (NNPs), alone or in combination with the bioadhesive Gantrez S-97, have demonstrated their efficacy against Streptococcus mutans; however, it is not known if this combination changes the color of teeth. The aim of this work was to measure the color changes occurring after the use of a Gantrez-NNP combination on enamel tooth blocks. Two study groups were randomly formed: enamel blocks brushed with (a) the Gantrez-NNP combination and (b) conventional toothpaste, for 1 minute once daily for 4 weeks, then rinsed with distilled water and placed in thymol solution. Color changes in the enamel blocks were measured using a Minolta colorimeter CR300. Analysis of mixed models was performed with R 2.10.1 at a 95% confidence level, using the nonlinear mixed effects (NLME) package. The results showed that there were no color changes over time, only a high luminosity equal in both groups. Our study showed that the use of the Gantrez-NNP combination is safe with respect to dental esthetics in the control of S. mutans.


Assuntos
Adesivos/química , Anti-Infecciosos Locais/química , Esmalte Dentário/anatomia & histologia , Maleatos/química , Nanopartículas Metálicas/química , Polivinil/química , Prata/química , Cor , Colorimetria/instrumentação , Humanos , Luminescência , Teste de Materiais , Descoloração de Dente/patologia , Cremes Dentais/química , Água/química
11.
J Clin Pediatr Dent ; 34(3): 275-9, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20578668

RESUMO

The purpose of this study was to determine the prevalence of oral manifestations in pediatric patients with acute lymphoblastic leukemia (ALL) receiving chemotherapy, and to evaluate the significance of independent risk factors (oral health, gender, age, time and type of treatment, and phase of chemotherapy). A cross-sectional study was made in 49 children with ALL between 2 and 14 years of age. To describe oral manifestations, a clinical diagnosis was made and the following criteria were applied: the OHI-S index to describe oral health and the IMPA index to describe periodontal conditions and to differentiate gingivitis from periodontitis. The prevalence of oral manifestations was: gingivitis, 91.84%; caries, 81.63%; mucositis, 38.77%; periodontitis, 16.32%; cheilitis, 18.36%; recurrent herpes, 12.24%; and primary herpetic gingivostomatitis, 2.04%. Other oral manifestations were: dry lips, mucosal pallor, mucosal petechiae, ecchymoses, and induced ulcers. The prevalence of oral candidiasis was 6.12%. It was observed that high risk ALL and poor oral hygiene were important risk factors for the development of candidiasis and gingivitis. The type of leukemia, gender and phase of chemotherapy were apparently associated with the presence of candidiasis, gingivitis, and periodontitis, and they could be considered risk factors for the development of oral manifestations.


Assuntos
Antineoplásicos/uso terapêutico , Doenças da Boca/epidemiologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Adolescente , Candidíase Bucal/epidemiologia , Queilite/epidemiologia , Criança , Pré-Escolar , Estudos Transversais , Cárie Dentária/epidemiologia , Equimose/epidemiologia , Feminino , Gengivite/epidemiologia , Humanos , Doenças Labiais/epidemiologia , Masculino , México/epidemiologia , Higiene Bucal , Úlceras Orais/epidemiologia , Periodontite/epidemiologia , Prevalência , Púrpura/epidemiologia , Fatores de Risco , Fatores Sexuais , Estomatite/epidemiologia , Estomatite Herpética/epidemiologia
12.
J Clin Pediatr Dent ; 35(2): 183-5, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21417121

RESUMO

UNLABELLED: Dental caries is a worldwide public health problem. S mutans plays an important role in the etiology of caries. There have been studies that showed the antimicrobial properties of silver nanoparticles are an effective agent to diminish S. mutans. The objective of this study was to evaluate the bactericidal and bacteriostatic effects of silver nanoparticles in addition to the Gantrez S-27 copolymer, on S mutans. METHOD: We performed an in vitro experimental study using the liquid microdilution method in order to find the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) with the subcultures obtained. The mixture was obtained by preparing 98 microg/mL of silver nanoparticles (10(3)mol) with Gantrez S-27 2%, in distilled water The readings were performed 24 hours after incubation and on 3 consecutive days. The results showed an average MTC of 6.12 microg /mL and MBC of 6.12 microg /mL. CONCLUSION: The addition of Gantrez 2% to silver nanoparticles does not alter its antimicrobial effect.


Assuntos
Antibacterianos/farmacologia , Maleatos/química , Nanopartículas/química , Polivinil/química , Compostos de Prata/farmacologia , Streptococcus mutans/efeitos dos fármacos , Antibacterianos/química , Humanos , Teste de Materiais , Testes de Sensibilidade Microbiana , Compostos de Prata/química , Fatores de Tempo
13.
Cir Esp ; 84(2): 83-6, 2008 Aug.
Artigo em Espanhol | MEDLINE | ID: mdl-18682186

RESUMO

INTRODUCTION: To identify the laboratory and ultrasound factors that could predict the response to medical treatment of amoebic liver abscess. MATERIAL AND METHOD: Retrospective study of patients diagnosis with amoebic liver abscess in Hospital Central in San Luis Potosí, Mexico. We included patients greater than 15 years of both sexes. We excluded those with probable pyogenic abscess, immunosupression, history of abdominal or biliary surgery, abdominal neoplasm abdominal or sepsis. We identified patients with good response to medical treatment and patients who needed the abscess drained. We studied the ultrasound findings, plasma levels of albumin, alkaline phosphatase and bilirubin. RESULTS: We analysed 45 patients, 31 had a good response (controls) and 14 needed drainage (cases). The medians of the variables with statistical significance in bivariate analysis were: albumin 2.65 g/dl and 1.7 g/dl (p < 0.001); alkaline phosphatase 133 U and 259 U (p = 0.02) and diameter of absences 5.9 cm and 9.95 cm (p < 0.001), controls and cases respectively. By logistic regression the diameter of the abscess showed a determination coefficient of 0.447 (p < 0.05) and OR = 14.85 (95% CI, 2.11-104.9) for drain if it was > or = 8 cm. CONCLUSIONS: A diameter bigger than 8 cm in hepatic amoebic abscess is associated with failure of medical treatment. Low albumin could be related to malnutrition and increased alkaline phosphatase with extrinsic compression of extrahepatic conducts due to big abscesses.


Assuntos
Abscesso Hepático Amebiano/diagnóstico , Abscesso Hepático Amebiano/terapia , Adolescente , Adulto , Idoso , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Retrospectivos , Falha de Tratamento , Adulto Jovem
14.
Nanomedicine ; 4(3): 237-40, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18565800

RESUMO

Dental caries is a worldwide public health problem for which Streptococcus mutans has been identified as the possible infectious etiology. In recent years nanotechnology has permitted the development of new properties of materials. The objective of this study was to compare the bactericidal and bacteriostatic effects of nanoparticles of silver, zinc oxide, and gold on S. mutans. We used the liquid dilution method to find the minimum inhibitory concentrations (MICs) and with subcultures obtained the minimum bactericidal concentrations (MBCs). For silver the results showed an average MIC of 4.86 +/- 2.71 microg/mL and MBC of 6.25 microg/mL; for zinc the MIC was 500 +/- 306.18 muicrog/mL and MBC of 500 microg/mL; the gold nanoparticles demonstrated an effect only at an initial concentration of 197 mug/mL. We established a higher antimicrobial effect against S. mutans of silver nanoparticles at lower concentrations than gold or zinc, which would allow achieving important clinical effects with a reduced toxicity.


Assuntos
Anti-Infecciosos/farmacologia , Ouro/farmacologia , Prata/farmacologia , Streptococcus mutans/efeitos dos fármacos , Óxido de Zinco/farmacologia , Testes de Sensibilidade Microbiana , Nanopartículas
15.
Gac Med Mex ; 143(3): 189-92, 2007.
Artigo em Espanhol | MEDLINE | ID: mdl-17722445

RESUMO

OBJECTIVE: Asess the efficacy of nebulized salbutamol and dexamethasone compared with nebulized salbutamol, in patients with bronchiolitis. MATERIAL AND METHODS: A blinded clinical trial was performed with 49 patients between 1-18 months diagnosed with bronchiolitis with three days or less of disease evolution. Participant's parents signed an informed consent and patients did not receive prior medication. Patients were randomly assigned to two groups: nebulized salbutamol or salbutamol plus dexamethasone, which they received every four hours during twenty-four hours. We measured heart and respiratory rate; respiratory distress index, oxygen saturation, and Silverman Andersen scores. RESULTS: No significant differences were found between groups for treatment response; but the frequency of hospital release at 24 hrs was significant among groups; 75 vs 96 % respectively (p = 0.04). CONCLUSIONS: The administration of salbutamol plus dexamethasone is more effective in the control of respiratory distress in children with bronchiolitis compared with the use of salbutamol alone.


Assuntos
Agonistas Adrenérgicos beta/administração & dosagem , Albuterol/administração & dosagem , Bronquiolite/tratamento farmacológico , Dexametasona/uso terapêutico , Glucocorticoides/uso terapêutico , Doença Aguda , Método Duplo-Cego , Feminino , Humanos , Lactente , Masculino , Nebulizadores e Vaporizadores
16.
J Clin Pediatr Dent ; 31(3): 183-6, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17550044

RESUMO

The aim of this study was to compare the clinical success of three conscious sedation regimens for pediatric dental patients. A clinical trial was performed wherein dental treatment was administered to pediatric patients ASA I and II under conscious sedation.. Fifty-four children were divided into three groups of 18 patients each, randomly assigned Group A received hydroxyzine (2 mg/kg 2 h before treatment and a subsequent dose of 1 mg/kg 20 min before treatment) orally; group B received 0.50 mg/kg midazolam mixed with 1.5 mg/kg hydroxyzine 20 min before treatment orally; group C received chloral hydrate, 50 mg/kg mixed with 1.5 mg/kg hydroxyzine 20 min before treatment orally. The Ohio State Behavioral Rating Scale (OSBRS) showed statistically significant differences between groups B and C with respect to group A. The regimens of midazolam or chloral hydrate mixed with hydroxyzine represent excellent choices for conscious sedation regimens for pediatric dental patients.


Assuntos
Anestesia Dentária/métodos , Comportamento Infantil/efeitos dos fármacos , Sedação Consciente/métodos , Assistência Odontológica para Crianças/métodos , Administração Oral , Anestésicos Combinados , Criança , Pré-Escolar , Hidrato de Cloral/administração & dosagem , Feminino , Frequência Cardíaca/efeitos dos fármacos , Antagonistas dos Receptores Histamínicos H1/administração & dosagem , Humanos , Hidroxizina/administração & dosagem , Hipnóticos e Sedativos/administração & dosagem , Lactente , Masculino , Midazolam/administração & dosagem , Estatísticas não Paramétricas
17.
Gac. méd. Méx ; 143(3): 189-192, mayo-jun. 2007. tab, graf
Artigo em Espanhol | LILACS | ID: lil-568752

RESUMO

Objetivo: Evaluar la eficacia de salbutamol y dexametasona nebulizados comparados con salbutamol solo en pacientes con bronquiolitis aguda. Material y métodos: Estudio clínico controlado, aleatorizado, en pacientes de 1 a 18 meses de edad con diagnóstico de bronquiolitis aguda y evolución menor de tres días. Se asignaron dos grupos: 1) salbutamol (n = 24) o 2) salbutamol más dexametasona (n = 25) administrado por micronebulizaciones cada cuatro horas por 24 horas. Se midieron las frecuencias cardiaca y respiratoria, la gravedad del cuadro mediante el Respiratory Distress Assigment Index, el Silvermann-Andersen, saturación de O2 y tiempo de desaparición de la dificultad respiratoria y frecuencia de altas en 24 horas. Resultados: No se encontraron diferencias significativas entre los grupos de estudio, excepto en la frecuencia de altas hospitalarias en las primeras 24 horas, 75 vs 96 % p < 0.04 respectivamente. Conclusiones: La aplicación de salbutamol más dexametasona es más rápida para controlar la dificultad respiratoria en niños con bronquiolitis aguda en comparación con la aplicación de salbutamol solo.


OBJECTIVE: Asess the efficacy of nebulized salbutamol and dexamethasone compared with nebulized salbutamol, in patients with bronchiolitis. MATERIAL AND METHODS: A blinded clinical trial was performed with 49 patients between 1-18 months diagnosed with bronchiolitis with three days or less of disease evolution. Participant's parents signed an informed consent and patients did not receive prior medication. Patients were randomly assigned to two groups: nebulized salbutamol or salbutamol plus dexamethasone, which they received every four hours during twenty-four hours. We measured heart and respiratory rate; respiratory distress index, oxygen saturation, and Silverman Andersen scores. RESULTS: No significant differences were found between groups for treatment response; but the frequency of hospital release at 24 hrs was significant among groups; 75 vs 96 % respectively (p = 0.04). CONCLUSIONS: The administration of salbutamol plus dexamethasone is more effective in the control of respiratory distress in children with bronchiolitis compared with the use of salbutamol alone.


Assuntos
Humanos , Masculino , Feminino , Lactente , Albuterol/administração & dosagem , Bronquiolite/tratamento farmacológico , Dexametasona/uso terapêutico , Glucocorticoides/uso terapêutico , Agonistas Adrenérgicos beta/administração & dosagem , Doença Aguda , Método Duplo-Cego , Nebulizadores e Vaporizadores
18.
Gac Med Mex ; 143(1): 11-5, 2007.
Artigo em Espanhol | MEDLINE | ID: mdl-17388091

RESUMO

OBJECTIVE: [corrected] Determine the extent to which levels of glycosylated hemoglobin levels among type 2 sedentary diabetic patients change when performing aerobic exercises two or three times a week. SETTING: Mexican Institute Social Security, Family Medicine Unit, primary care level. STUDY DESIGN: Controlled clinical trial. METHODS AND SUBJETS: Two groups of 25 participants carried out a comprehensive exercise routine 2 or 3 times per week in alternate days. Measurements were done at baseline, 8 and 16 weeks. HbA1c, aerobic capacity, BMI and compliance were assesed. OUTCOME: There was no significant difference in HbA1c between the two study groups, however both groups showed lower levels of HbA1c when comparing their baseline and follow up levels (p < 0.001). No significant association was found between Hb1Ac, aerobic capacity or BMI. Compliance was higher among the group exercising 2 days. CONCLUSION: Moderate aerobic exercise was well tolerated showing a significant decrease on HbA1c even among the 2 day group.


Assuntos
Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/terapia , Terapia por Exercício/métodos , Hemoglobinas Glicadas/análise , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Tempo
19.
Gac. méd. Méx ; 143(1): 11-15, ene.-feb. 2007. tab
Artigo em Espanhol | LILACS | ID: lil-568897

RESUMO

Objetivo. Determinar el cambio en la hemoglobina glucosilada (HbA1c) en pacientes diabéticos tipo 2 sedentarios al realizar ejercicio aeróbico 2 o 3 veces por semana en días alternos. Se realizó en la Unidad de Medicina Familiar del Instituto Mexicano del Seguro Social en San Luis Potosí, con el diseño de un ensayo clínico controlado. Material y métodos. Se integraron dos grupos (n = 25) de ejercicio de 2 y 3 veces por semana en días alternos. Mediciones de los valores basales, 8 y 16 semanas de hemoglobina glucosilada A1c (HbA1c), capacidad aeróbica, índice de masa corporal (IMC) y cumplimiento. Resultados. No se encontró diferencia significativa en HbA1c entre los dos grupos de estudio, pero sí al comparar sus valores basales (p <0.001). No se encontró correlación significativa entre la HbA1c y el cambio de capacidad aeróbica o el IMC. El porcentaje de cumplimiento fue mayor en el grupo de 2 días de ejercicio. Conclusiones. El ejercicio aeróbico de intensidad moderada es bien tolerado, obteniendo una reducción significativa de HbA1c y se constata mejor cumplimiento en el grupo de 2 días.


OBJECTIVE: Determine the extent to which levels of glycosylated hemoglobin levels among type 2 sedentary diabetic patients change when performing aerobic exercises two or three times a week. SETTING: Mexican Institute Social Security, Family Medicine Unit, primary care level. STUDY DESIGN: Controlled clinical trial. METHODS AND SUBJETS: Two groups of 25 participants carried out a comprehensive exercise routine 2 or 3 times per week in alternate days. Measurements were done at baseline, 8 and 16 weeks. HbA1c, aerobic capacity, BMI and compliance were assesed. OUTCOME: There was no significant difference in HbA1c between the two study groups, however both groups showed lower levels of HbA1c when comparing their baseline and follow up levels (p < 0.001). No significant association was found between Hb1Ac, aerobic capacity or BMI. Compliance was higher among the group exercising 2 days. CONCLUSION: Moderate aerobic exercise was well tolerated showing a significant decrease on HbA1c even among the 2 day group.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , /sangue , /terapia , Hemoglobinas Glicadas/análise , Terapia por Exercício/métodos , Fatores de Tempo
20.
Gac Med Mex ; 141(5): 445-7, 2005.
Artigo em Espanhol | MEDLINE | ID: mdl-16353894

RESUMO

OBJECTIVE: To obtain the profile of students that deserted from the Faculty of Medicine of the Autonomous University of San Luis Potosi, México. DESIGN: Cases and controls nested in a cohort. METHODS: All students that voluntarily deserted between 1992 and 2002 were consulted. Each student was compared in an aleatory form with a regular student and a proper questionnaire was applied. RESULTS: The significantly associated factors to abandon the Faculty of Medicine were: high school of origin (OR=2.43), extra-ordinary exam (OR=3.13), and lack of vocation (OR=2.41). CONCLUSION: The subjacent factors for not deserting from the Faculty of Medicine were: study habits, capacity for sustained effort, and tolerance to frustration.


Assuntos
Faculdades de Medicina , Evasão Escolar/estatística & dados numéricos , Adolescente , Estudos de Casos e Controles , Feminino , Humanos , Masculino , México , Fatores de Risco , Estudantes de Medicina
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